楊雅甄(Ya-Chen Yang)
姓名 楊雅甄(Ya-Chen Yang)
學歷 美國食品藥物管理局 生化毒理所 博士後研究員
現職 亞洲大學食品營養與保健生技學系 副教授
電子郵件
分機 04-23323456#1839
研究室 I525
專長 生化毒理、有機合成、化妝品學和中草藥研究
教師歷程檔案 教師歷程檔案
教師在校時程表 在校時程表
年度 論文名稱
2023 Te-Cheng Yueh、Yun-Chi Wang、Yu-Ting Chin、Yi-Chih Hung、蒙美津(Mei-Chin Mong)、楊雅甄(Ya-Chen Yang)、Jen-Sheng Pei、Da-Tian Bau(Da-Tian Bau)*、Wen-Shin Chang, Impact of Mir196a-2 Genotypes on Colorectal Cancer Risk in Taiwan, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol.24 pp.11613-11613, 2023
2023 Yen, Chih-Ching、Lii, Chong-Kuei、Chen, Chih-Chieh、Li, Chien-Chun、Tseng, Meng-Hsien、Lo, Chia-Wen、Liu, Kai-Li、楊雅甄(Ya-Chen Yang)、Chen, Haw-Wen(Chen, Haw-Wen)*, Andrographolide Inhibits Lipotoxicity-Induced Activation of the NLRP3 Inflammasome in Bone Marrow-Derived Macrophages, AMERICAN JOURNAL OF CHINESE MEDICINE, vol.51 no.1 pp.129-147, 2023
2023 SHANG-MIAO CHANG、楊雅甄(Ya-Chen Yang)、GUAN-LIANG CHEN、DA-TIAN BAU(DA-TIAN BAU)*, The Association of DNA Ligase 1 Rs20579 Polymorphism With Lung Cancer Risk Among Taiwanese, IN VIVO, vol.37 pp.1504-1510, 2023
2022 Yueh, Te-Cheng、Tsao, Hao-Yuan、Chien, Wei-Ching、Tsai, Chia-Wen、Pei, Jen-Sheng、Wu, Ming-Hsien、Wang, Zhi-Hong、Mong, Mei-Chin、楊雅甄(Ya-Chen Yang)、Bau, Da-Tian(Bau, Da-Tian)*, The Contribution of Matrix Metalloproteinase-7 Promoter Genotypes to Hepatocellular Carcinoma Susceptibility, ANTICANCER RESEARCH, vol.42 no.11 pp.5275-5282, 2022
2022 Yueh, Te-Cheng、Hung, Yi-Chih、Lee, Hsu-Tung、Yang, Mei-Due、Wang, Zhi-Hong、楊雅甄(Ya-Chen Yang)、Ke, Tao-Wei、Pei, Jen-Sheng、Tsai, Chia-Wen、Bau, Da-Tian(Bau, Da-Tian)*, Role of Matrix Metallopeptidase-2 Genotypes in Taiwanese Patients with Colorectal Cancer, ANTICANCER RESEARCH, vol.42 no.11 pp.5335-5342, 2022
2022 CHUN-KAI FU、蒙美津(Mei-Chin Mong)、CHIEN-CHIH YU、MEI-DUE YANG、王智弘(Wang Zhi-Hong)、楊雅甄(Ya-Chen Yang)、DA-TIAN BAU, Association of Matrix Metallopeptidase-2 Genotypes With Risk of Gastric Cancer in Taiwan, ANTICANCER RESEARCH, vol.42 pp.1749-1755, 2022
2022 李嘉翔(Chun-Che Lin)、楊雅甄(Ya-Chen Yang)、TE-CHUN HSIA、TE-CHUN SHEN、YI-CHENG SHEN、WEN-SHIN CHANG、DA-TIAN BAU(DA-TIAN BAU)*, Association of Interleukin-8 Promoter Genotypes With Taiwan Lung Cancer Risk, ANTICANCER RESEARCH, vol.42 pp.1229-1236, 2022
2022 JEN-SHENG PEI、WEN-SHIN CHANG、PEI-CHEN HSU、CHAO-CHUN CHEN、楊雅甄(Ya-Chen Yang)、SHIH-WEI HSU、DA-TIAN BAU2, Contribution of Cyclin-dependent Kinase Inhibitor 1B Genotypes to Childhood Leukemia Risk, IN VIVO, vol.36 pp.1637-1642, 2022
2022 MENG-FENG WU、LI-HSIOU CHEN、NING-YI HSIA、YI-CHENG SHEN、TE-CHUN SHEN1、Wang Zhi-Hong、楊雅甄(Ya-Chen Yang)、DA-TIAN BAU, Significant Contribution of Interleukin-18 Genotypes to Lung Cancer Risk in Taiwanese, ANTICANCER RESEARCH, vol.42 pp.3381-3387, 2022
2021 羅佳文(Chia-Wen Lo)、Chong-Kuei Lii、Jian-Jhe Hong、Wei-Ting Chuang、楊雅甄(Ya-Chen Yang)、Haw-Wen Chen, Andrographolide inhibits IL-1β release in bone marrow-derived macrophages and monocyte infiltration in mouse knee joints induced by monosodium urate, TOXICOLOGY AND APPLIED PHARMACOLOGY, vol.410 no.1 pp.115341-115341, 2021
2021 Chun-Che Lin、楊雅甄(Ya-Chen Yang)、Chia-Yu Chen、殷湄晶(Mei-chin Yin)*, Combination of s-methyl cysteine and protocatechuic acid provided greater lipid-lowering and anti-inflammatory effects in mice liver against chronic alcohol consumption., Iranian Journal of Basic Medical Sciences, 2021
2021 陳智傑(Chih-Chieh Chen)、Chong-Kuei Lii、Chia-Wen Lo、Yi-Hsueh Lin、楊雅甄(Ya-Chen Yang)、Chin-Shiu Huang、Haw-Wen Chen, 14-Deoxy-11,12-Didehydroandrographolide Ameliorates Glucose Intolerance by Enhancing the LKB1/AMPKα/TBC1D1/ GLUT4 Signaling Pathway and Inducing GLUT4 Expression in Myotubes and Skeletal Muscle of Obese Mice, The American journal of Chinese medicine, vol.49 no.6 pp.1473-1491, 2021
2021 傅茂祖(Mao-Tsu Fuh)、Chin-Chun Tseng、Sin-Min Lee、Chuo-En Tsai、Chih-Hao Lu、楊雅甄(Ya-Chen Yang)、翁豐富(Fung Fuh Wong), Design, synthesis and biological evaluation of glycolamide, glycinamide, and β-amino carbonyl 1,2,4-triazole derivatives as DPP-4 inhibitors, BIOORGANIC CHEMISTRY, vol.114 pp.105049-, 2021
2020 楊雅甄(Ya-Chen Yang)、蒙美津(Mei-Chin Mong)、吳文慈(Wen-Tzu Wu)、王智弘(Wang Zhi-Hong)、殷湄晶(Mei-chin Yin), Phytochemical profiles and anti-diabetic benefits of two edible Amaranthus species, CyTA-Journal of Food, vol.18 no.1 pp.94-101, 2020
2020 Chih-Chieh Chen、Chong-Kuei Lii、Yi-Hsueh Lin、Pei-Hsin Shi、楊雅甄(Ya-Chen Yang)、Chin-Shiu Huang、Haw-Wen Chen, Andrographis paniculata Improves Insulin Resistance in High-Fat Diet-Induced Obese Mice and TNFα-Treated 3T3-L1 Adipocytes, The American journal of Chinese medicine, vol.48 pp.1073-1090, 2020
2020 翁豐富(Fung-Fuh Wong)、楊雅甄(Ya-Chen Yang), Chlorotrimethylsilane promoted one-flask heterocyclic synthesis of 1,2,4- triazoles from nitrilimines: Modeling studies and bioactivity evaluation of LH-21 and Rimonabant analogues, BIOORGANIC CHEMISTRY, vol.104 no.1 pp.104299-104299, 2020
2020 Sin-Min Li、Shuo-En Tsai、Chia-Yin Chiang、Fung-Fuh Wong、楊雅甄(Ya-Chen Yang), New methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: Design, synthesis, biological evaluation, and docking study, BIOORGANIC CHEMISTRY, vol.104 no.1 pp.104333-104333, 2020
2019 C. C. Yen、Y. T. Liu、楊雅甄(Ya-Chen Yang)、C. C. Chen、H. W. Chen, Bioavailability of the diterpenoid 14-deoxy-11,12-didehydroandrographolide in rats and up-regulation of hepatic drug-metabolizing enzyme and drug transporter expression, PHYTOMEDICINE, vol.61 pp.152841-152845, 2019
2019 Hung-Chih Lin、Chong-Kuei Lii、Ai-Hsuan Lin、Chien-Chun Li、Chia-Han Tsai、Shiuan-Kai Pan、楊雅甄(Ya-Chen Yang)、Haw-Wen Chen, Docosahexaenoic acid inhibits TNFα-induced ICAM-1 expression by activating PPARα and autophagy in human endothelial cells, FOOD AND CHEMICAL TOXICOLOGY, vol.134 pp.110811-, 2019
2018 楊雅甄(Ya-Chen Yang)、王智弘(Wang Zhi-Hong)、殷湄晶(Mei-chin Yin)*, Content of nitric oxide and glycative compounds in cured meat products-Negative impact upon health, BioMedicine, vol.8 no.2 pp.28-33, 2018
2017 林鴻林(Hung-Chih Lin)*、楊雅甄(Ya-Chen Yang), Andrographolide Inhibits Hypoxia-Induced HIF-1a-Driven Endothelin 1 Secretion by Activating Nrf2/HO-1 and Promoting the Expression of Prolyl Hydroxylases 2/3 in Human Endothelial Cells, Environmental Toxicology, vol.32 no.3 pp.918-930, 2017
2016 楊雅甄(Ya-Chen Yang)、陳暉雯(Haw Wen Chen)*, Docosahexaenoic acid inhibits inflammation via Free Fatty Acid Receptor FFA4, disruption of TAB2 interaction with TAK1/TAB1, and down-regulation of ERK-dependent Egr-1 expression in EA.hy926 cells, MOLECULAR NUTRITION & FOOD RESEARCH, vol.60 pp.430-443, 2016
2015 謝承紘(Cheng-Hong Hsieh)、李傳珍(Chuan-Chen Lee)、楊雅甄(Ya-Chen Yang)*, Hepatotoxic pyrrolizidine alkaloids in Emilia sonchifolia from Taiwan, JOURNAL OF FOOD COMPOSITION AND ANALYSIS, vol.215 pp.1-7, 2015
2014 楊雅甄(Ya-Chen Yang)、謝承紘(Cheng-Hong Hsieh), Authentication of consumer fraud in Taiwanese fish products by molecular trace evidence and forensically informative nucleotide sequencing, FOOD RESEARCH INTERNATIONAL, vol.55 pp.294-302, 2014
2014 楊雅甄(Ya-Chen Yang), Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells., BIOCHEMICAL PHARMACOLOGY, vol.91 no.1 pp.40-50, 2014
2013 楊雅甄(Ya-Chen Yang), Docosahexaenoic acid inhibition of inflammation is partially via cross-talk betweenNrf2/heme oxygenase 1 and IKK/NF-κB pathways, JOURNAL OF NUTRITIONAL BIOCHEMISTRY, vol.24 pp.204-212, 2013
2012 楊雅甄(Ya-Chen Yang)、Shaw-Tao Lin, Conformational Analysis of trans- 2,11-Dithia-4e,5,6,7e,8,9-hexahydro[3.3]paracyclophane Using VT-NMR, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol.59 no.2 pp.373-377, 2012
2012 楊雅甄(Ya-Chen Yang)、謝承紘(Cheng-Hong Hsieh), A unique specification method for processed unicorn filefish products using a DNA barcode marker, FOOD CONTROL, vol.25 no.1 pp.292-302, 2012
2011 楊雅甄(Ya-Chen Yang)、Chong-Kuei Lii、Haw-Wen Chen, Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress, FREE RADICAL BIOLOGY AND MEDICINE, vol.51 pp.2073-2081, 2011
2008 楊雅甄(Ya-Chen Yang)、Shaw-Tao Lin(Shaw-Tao Lin,)*、Wen-Shing Ch, Tetrathiadodeca-hydro[3.3.3.3]paracyclophane Complexed with Copper(I) and Silver(I) complexes, JOURNAL OF CHEMICAL RESEARCH-S pp.280-284, 2008
2007 楊雅甄(Ya-Chen Yang), Synthesis and Structural Study ofCopper(I) or Silver(I) Complexes of 2,11-dithia-4,5,6,7,8,9-hexahydro[3.3]-paracyclophanes, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol.54 pp.587-594, 2007
2006 李傳珍(Chuan-Chen Lee)、楊雅甄(Ya-Chen Yang), Carbon-13 NMR and PM3 Study on the Substituent Effect of 1-Aryl-3,3-difluoro-2- halocyclopropenes, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol.53 pp.915-921, 2006
2005 Preparation and spectroscopic1 study of 13-substituted 2,11-dithiahexahydro[3.3]paracyclophanes, JOURNAL OF CHEMICAL RESEARCH-S pp.708.-717, 2005
2003 楊雅甄(Ya-Chen Yang)、、, Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine riddelliine, TOXICOLOGY LETTERS, vol.145 pp.239--247, 2003
2002 楊雅甄(Ya-Chen Yang), Pyrrolizidine Alkaloids - Tumorigenic Components in Chinese Herbal Medicines and Dietary Supplements, JOURNAL OF FOOD AND DRUG ANALYSIS, vol.10 pp.198-211, 2002
2002 楊雅甄(Ya-Chen Yang), Detection of Riddelliine-Derived DNA Adducts in Blood of Rats Fed Riddelliine, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol.3 pp.1019-1026, 2002
2001 Peter. P. Fu,、Ming W. Chou,、Q. Xia、楊雅甄(Ya-Chen Yang), Genotoxic Pyrrolizidine Alkaloid N-oxides-Mechanism Leading to DNA Adduct Formation and Tumorigenicity., JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGEN, vol.19, 2001
2001 楊雅甄(Ya-Chen Yang), Metabolic Activation Pathways of the Pyrrolizidine Alkaloid, Riddelliine, Leading to DNA Adduct Formation in Vivo, CHEMICAL RESEARCH IN TOXICOLOGY, vol.14 pp.101-109, 2001
2001 楊雅甄(Ya-Chen Yang), Development of a 32P-Postlabelling/HPLC Method for Detection of Dehydroretronecine-Derived DNA Adducts In Vitro and In Vivo;, CHEMICAL RESEARCH IN TOXICOLOGY, vol.14 pp.91-100, 2001
2001 楊雅甄(Ya-Chen Yang), Preparation of Hydroquinone-Containing Polymers by ROMP, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, vol.48 pp.945-948, 2001
發表日期 論文名稱
2021.06 詹巧羽(Qiao-Yu Zhan)、許羽鎔(Yu-Jung Hsu)、翁韻純(Yun-Chun Weng)、張筱筠(Hsiao-Chuan Chang)、楊雅甄(Ya-Chen Yang), 花蓮澤蘭中肝毒性?咯里西啶生物鹼之檢測 , 2021中亞聯大生物科技研討會, Jun. 2021, 台灣/台中
2021.06 許羽鎔(Yu-Jung Hsu)、詹巧羽(Qiao-Yu Zhan)、楊雅甄(Ya-Chen Yang), 康復力植物中?咯里西啶生物鹼之檢測及定量分析 , 中亞聯大生物科技研討會, Jun. 2021, 台灣/台中
2020.05 莊宏晨、詹巧羽、簡妤庭、楊雅甄(Ya-Chen Yang), 台灣澤蘭中肝毒性?咯里西啶生物鹼之檢測 , 2020 年中國醫藥大學暨亞洲大學生物科技研討會, May. 2020, 台灣/台中
2020.05 翁韻純、許羽鎔、盧映淇、楊雅甄(Ya-Chen Yang), Determination of Hepatotoxic Pyrrolizidine Alklaloids in Adenostemma lavenia (L.) O. Kuntze , 2020 年中國醫藥大學暨亞洲大學生物科技研討會, May. 2020, 台灣/台中
2018.06 衛柏成(Po-Cheng Wei)、楊雅甄(Ya-Chen Yang), Hepatotoxic Pyrrolizidine Alkaloids in Tussilago Farfara L. from Taiwan. , 2018生物醫學國際研討會, Jun. 2018, 中國醫藥大學
2017.06 Identification and Quantitative Analysis of Pyrrolizidine Alkaloids in Crotalaria Verrucosa L. from Taiwan , 2017 BEST Conference & International Symposium, Jun. 2017, National Yunlin University of Science and Technology, Yunlin, Taiwan
2017.05 卓辰陽(Chen-Yang Cho)、衛柏成(Po-Chen Wei)、莊宏晨(Hong-Chen Jhuang)、鄭翎雲(Ling-Yun Cheng)、王懷忻(Hvai-Hsin Wang)、楊雅甄(Ya-Chen Yang), Exploring Hepatotoxic Pyrrolizidine Alkaloids in Crotalaria Verrucosa (L.) , The 10th Biotechnology conference Asia University, May. 2017, Asia University
2015.07 楊雅甄(Ya-Chen Yang)、卓辰陽(Chen-Yang Cho)、邱登慶(Deng-Qing Qiu), Detection of hepatotoxic pyrrolizidine alkaloids in Mimosa pudica by gas chromatography mass spectrometry , 25th Australian and New Zealand Society for Mass Spectrometry and 6th Asia Oceania Mass Spectrometry, Jul. 2015, Australia
2015.07 卓辰陽(Chen-Yang Cho)、邱登慶(Deng-Cing Ciou), Detection of pyrrolizidine alkaloids in Emilia sonchifolia using liquid chromatography, electrospray ionization mass spectrometry - World Congress on Pharmacology, Jul. 2015, Brisbane, Australia
2013.03 林怡諄(Yi-Zhun Lin)、邱登慶(Deng-Qing Qi)、謝承紘(Cheng-Hong Hsieh)、楊雅甄(Ya-Chen Yang), Quantitative Analysis Of Some Pyrrolizidine Alkaloids In Mimosa pudica by Gas Chromatography, Mass Spectrometry;The 6th Joint Conference on Biotechnology Asia University and China Medical University: p63;台中,台灣 - The 6th Joint Conference on Biotechnology, Mar. 2013, Asia University
2011.07 吳浩洋(Hao-Yang Wu)、賴德宏(De-Hong Lai)、邱登慶(Deng-Qing Qiu)、楊雅甄(Ya-Chen Yang), Identification and Quantification of Hepatotoxic Pyrrolizidine Alkaloids in Heliotropium indicum L. , 2011第八屆台灣質譜年會暨學術研討會, Jul. 2011, 台北
2009.09 楊雅甄(Ya-Chen Yang), DETERMINATION OF HEPATOTOXIC PYRROLIZIDINE ALKALOIDS IN EMILIA SONCHIFOLIA BY GC, MS - International Congress of Asian Society of Toxicology, Sep. 2009, Taipei, Taiwan
2008.12 黃少紘(Shao-Hong Huang)、劉彩琳(Cai-Ling Liou)、何寶瑜(Bao-Yu He)、楊雅甄(Ya-Chen Yang), Determination of hepatotoxic pyrrilizidine alkaloids in Tussilago farfara L. by GC, MS - 97年中國化學年會, Dec. 2008, 彰化
計畫名稱 參與人 計畫期間
檢測康復力中所含肝毒性?咯里西啶類生物鹼之研究 (MOST 109-2320-B-468-001 -) 楊雅甄(Ya-Chen Yang) 2020.08 ~ 2021.10
中草藥藤紫丹中肝毒性?咯里西啶生物鹼之檢測 (MOST 108-2635-B-468-001 -) 楊雅甄(Ya-Chen Yang) 2019.08 ~ 2020.07
以LC/MS/MS檢測紫背草之?咯啶生物鹼含量和毒性之研究 (NSC102-2313-B-468 -003) 楊雅甄(Ya-Chen Yang) 2013.08 ~ 2014.07
台灣中草藥紫背草之檢測及肝毒性之研究 (101-2313-B-468 -003) 楊雅甄(Ya-Chen Yang) 2012.08 ~ 迄今
食品安全性研究-河魨製品相關之基因定性定量研究與毒素之基因毒理探討 (20110624114730) 楊雅甄(Ya-Chen Yang) 2009.08 ~ 2010.07
年度 名稱 全部作者
107 款冬花製品與藤紫丹中肝毒性?咯里西啶生物鹼之檢測 衛柏成
106 台灣大葉野百合中所含肝毒性?咯里西啶類生物鹼之研究
102 開發LC/MS/MS檢測紫背中吡咯啶類生物鹼之方法 林怡諄
102 篦麻選育栽培及油脂分析之研究 張世欣
101 以氣相層析質譜儀檢測含羞草中所含肝毒性雙稠?咯啶類生物鹼 賴德宏
100 以GC-MS檢測耳鉤草中所含肝毒性雙稠吡咯啶類生物鹼 吳浩洋
098 以GC-MS檢測康復力中所含肝毒性雙稠吡咯啶類生物鹼 劉彩琳
098 以GC-MS檢測紫背草中所含雙稠吡咯啶類生物鹼 何寶瑜
098 以GC-MS檢測款冬花中所含致癌性之芘咯定生物鹼 黃少紘